Recent endeavors on molecular imaging for mapping metals in biology

• 作者: Jing Gao Yuncong Chen Zijian Guo Weijiang He
• 来源期刊: 生物物理学报
• 年，卷（期）: 2020,（5）
• 所属期刊栏目: REVIEW
• 页码范围: 159-178
• 页数: 20页
• 语种: 中文
• DOI: 10.3969/j.issn.1000-6737.2020.05.002

摘要

Transition metals such as zinc,copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems.Molecular imaging including two-photon imaging (TPI),bioluminescence imaging (BLI) and photoacoustic imaging (PAI),could act as non-invasive toolkits for capturing dynamic events in living cells,tissues and whole animals.Herein,we review the recent progress in the development of molecular probes for essential transition metals and their biological applications.We emphasize the contributions of metallostasis to health and disease,and discuss the future research directions about how to harness the great potential of metal sensors.