Single-Cell RNA Expression Profiling of ACE2 and AXL in the Human Maternal-Fetal Interface

• 作者: Duan Tao Jin Li-Ping Zheng Qing-Liang
• 来源期刊: 生殖与发育医学（英文）
• 关键词: 2019 Novel Coronavirus Disease ACE2 AXL Maternal-Fetal Interface Severe Acute Respiratory Syndrome Coronavirus 2 Vertical Transmission
• 年，卷（期）: 2020,（1）
• 所属期刊栏目: Expert Reviews
• 页码范围: 7-10
• 页数: 4页
• 语种: 中文
• DOI: 10.4103/2096-2924.278679

摘要

2019 novel coronavirus disease has resulted in thousands of critically ill patients in China, which is a serious threat to people’s life and health. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was reported to share the same receptor, angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Here, based on the public single-cell RNA-sequencing database, we analyzed the mRNA expression profile of putative receptor ACE2 and AXL receptor tyrosine kinase (AXL) in the early maternal-fetal interface. The result indicates that the ACE2 has very low expression in the different cell types of early maternal-fetal interface, except slightly high in decidual perivascular cells cluster 1 (PV1). Interestingly, we found that the Zika virus (ZIKV) receptor AXL expression is concentrated in perivascular cells and stromal cells, indicating that there are relatively more AXL-expressing cells in the early maternal-fetal interface. This study provides a possible infection route and mechanism for the SARS-CoV-2- or ZIKV-infected mother-to-fetus transmission disease, which could be informative for future therapeutic strategy development.