Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

• 作者: Yingsi Xie Ruslan G.Tuguntaev Cong Mao Haoting Chen Ying Tao Shixiang Wang Bin Yang Weisheng Guo
• 来源期刊: 生物物理学报
• 年，卷（期）: 2020,（5）
• 所属期刊栏目: REVIEW
• 页码范围: 193-210
• 页数: 18页
• 语种: 中文
• DOI: 10.3969/j.issn.1000-6737.2020.05.004

摘要

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane.Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines.Therefore,the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy.Nowadays,the nanocarrier system incorporated with stimuli-responsive property is being intensively studied,showing the potentially tremendous value of specific therapy.Stimuli-responsive (i.e.,pH,temperature,light,redox,and enzyme) polymeric nanomaterials,as an important component of nanoparticulate carriers,have been intensively developed for various diseases treatment.A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored.The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations.Herein,we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA.The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.