Flavonoids with cytotoxicities from the seeds of Pongamia pinnata(L.)Pierre

• 作者: Di Zhou Gang Chen Jiaxin Qi Ning Li Wanru Jiang Yuan Gao
• 来源期刊: 亚洲传统医药
• 学科: 化学
• 关键词: Pongamia pinnata(L.)Pierre CONSTITUENT FLAVONOIDS cytotoxicities
• 年，卷（期）: 2020,（4）
• 页码范围: 153-163
• 页数: 11页
• 分类号: O62

摘要

Twenty-eight compounds,including flavones(2,4-5,7-11),flavonols(1,3,6,21,22),flavanones(12-18),isoflavones(19,20),chalcones(23,24),phenylpropanoids(25,26),and others(27,28)were isolated from the ethanol extract of the seeds of Pongamia pinnata(L.)Pierre and identified on the basis of physic-chemical constants and spectral analysis(NMR,ECD,[α]^20 D).Among them,compounds 16,18,21,23,25 and 26 were obtained from the genus for the first time.The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays.As a result,compounds 14 and 15 displayed moderate cytotoxicities.