At present,COVID-19 is outbreaking worldwide,and the severity of the disease is closely related to the intensity of cytokine storm and inflammatory response.Cytokine storm is an excessive immune response to external stimuli,with complex pathogenesis and high mortality.In the New Coronavirus Infected Pneumonia Diagnosis and Treatment Program,a variety of measures are recommended for treatment,such as respiratory support,circulatory support,glucocorticoids and traditional Chinese medicine prescriptions to suppress the cytokine storm in the late clinical stage.At present,the combination of traditional Chinese medicine and Western medicine has achieved good results in clinical practice.Traditional Chinese medicine has contributed greatly to human health and world civilization,and is also a characteristic health resource in China.It has been adhering to the principle of"treating the symptoms at the time and treating the root cause in ordinary time",and has shown obvious efficacy in a variety of immune diseases.Ocean occupies 70%of the earth's surface,which contains abundant resources of traditional Chinese medicine.This paper analyzed the effect of marine algae traditional Chinese medicine on cytokine storm and immune regulation,hoping to provide a supplement to the existing application of traditional Chinese medicine,and provide some references for the development of drugs to inhibit cytokine storm from the sea.