Protective Effect of the Zhuang Medicine Cryptolepis buchananii Roem. et Schult. on D-GalN-induced Liver Injury in Mice

• 作者: Chenyan LIANG Ganneng HUANG Li WANG Liuyan HE Lu ZHANG Mingcheng CHEN Yunli TANG
• 来源期刊: 农业生物技术:英文版
• 学科: 医学
• 关键词: Cryptolepis buchananii Roem.et Schult. D-GALACTOSAMINE Liver injury
• 年，卷（期）: 2020,（1）
• 页码范围: 60-62
• 页数: 3页
• 分类号: R57

摘要

[Objectives] This study was conducted to study the protective effect of the Zhuang medicine Cryptolepis buchananii Roem. et Schult. on D-galactosamine(D-GalN)-induced liver injury in mice. [Methods] A mouse model of chemical liver injury was established by D-GalN, and the mice with D-GalN-induced liver injury were randomly divided into the blank group, model group, positive control group and drug-administered groups. The levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the serum of the mice in each group and the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in the liver tissue of the mice were determined, and the liver pathological changes were observed. [Results] The extracts of the Zhuang medicinal herb C. buchananii could reduce the serum ALT and AST levels(P<0.05), increase the SOD content in the liver tissue of mice(P<0.05), and decrease the MDA level(P<0.05). [Conclusions] The Zhuang medicinal herb C. buchananii has a good protective effect on D-GalN-induced liver injury in mice.