Mechanisms of repetitive transcranial magnetic stimulation for antidepression: Evidence from preclinical studies

• 作者: Di Luan Hai-Xia Feng Ling Li Ming-Ge Zhao Ya-Chen Shi Yu-Jia Cao Zhi-Jun Zhang
• 来源期刊: 世界精神病学杂志
• 学科: 工学
• 关键词: Repetitive transcranial magnetic stimulation Anti-depressant mechanisms Nuclear factor-e2-related factor 2 Endocannabinoid system Monoamine oxidase Hypothalamic-pituitary-adrenocortical axis Brain derived neurotrophic factor
• 年，卷（期）: 2020,（10）
• 页码范围: 223-233
• 页数: 11页
• 分类号: TG1

摘要

This review summarizes the anti-depressant mechanisms of repetitive transcranial magnetic stimulation in preclinical studies,including anti-inflammatory effects mediated by activation of nuclear factor-E2-related factor 2 signaling pathway,anti-oxidative stress effects,enhancement of synaptic plasticity and neurogenesis via activation of the endocannabinoid system and brain derived neurotrophic factor signaling pathway,increasing the content of monoamine neurotransmitters via inhibition of Sirtuin 1/monoamine oxidase A signaling pathway,and reducing the activity of the hypothalamic-pituitary-adrenocortical axis.We also discuss the shortcomings of transcranial magnetic stimulation in preclinical studies such as inaccurate positioning,shallow depth of stimulation,and difficulty in elucidating the neural circuit mechanism up-and down-stream of the stimulation target brain region.