A systematic review and meta-analysis to compare the effects of Chinese herbal pieces and granule in different diseaseherbal pieces

• 作者: Chang-Gang Sun Jing-Bo Zhai Lu Wang Yang Yu
• 来源期刊: TMR整合医学
• 学科: 医学
• 关键词: TCM granules TCM herbal pieces Cold Hypertension Osteoporosis Digestive system diseases MIGRAINES META-ANALYSIS
• 年，卷（期）: 2020,（18）
• 页码范围: 1-27
• 页数: 27页
• 分类号: R28

摘要

Objective:Compared to Chinese herbal piecesherbal pieces,the quality of TCM granule is stable and controllable,it is also a convenient alternative to decocting herbs.However,whether they are as clinically effective as Chinese herbal piecesherbal pieces is still controversial.In this study,a systematic review and meta-analysis were performed to assess the clinical efficacy of TCM granules and Chinese herbal piecesherbal pieces.Methods:A search of online databases for eligible articles was performed,including PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Internet,WanFang,and Chongqing VIP Information,searching from the inception of these databases to 2020.The Cochrane Handbook 5.1.0 was used to independently identify the trials,extract data,and assess the risk of bias.The meta-analysis was performed via RevMan 5.3 software.Results:A total of 98 eligible articles were included.After classification and statistical analysis of the related diseases,a meta-analysis was performed on 8 types of illnesses(cold,hypertension,migraine,osteoporosis,and diseases of the digestive system,such as gastritis,gastric ulcer,colitis,epigastric pain)included in 66 randomized controlled trials to compare the clinical efficacy and adverse events of TCM granules and Chinese herbal pieces.Meta-analysis showed that compared with Chinese herbal piecesherbal pieces,TCM granules had similar effectiveness and safety in treating cold,hypertension,and osteoporosis,but a higher response rate in migraines and a better effect in reducing migraine duration and higher response rate on diseases of the digestive system.Conclusion:Compared with the traditional decoctions,TCM formula granules had the same efficacy and safety,moreover,they had higher efficacy and safety in treating migraines and digestive system diseases.