Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 32-41
• 页数: 10页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz055

摘要

Adult progenitor cells activation is a key event in the formation of adult organs.In Drosophilo,formation of abdominal adult trachea depends on the specific activation of tracheal adult progenitors (tracheoblasts) at the Tr4 and Tr5 spiracular branches.Proliferation of these tracheoblasts generates a pool of tracheal cells that migrate toward the posterior part of the trachea by the activation of the branchless/fibroblast growth factor (Bnl/FGF) signaling to form the abdominal adult trachea.Here,we show that,in addition to migration,Bnl/FGF signaling,mediated by the transcription factor Pointed,is also required for tracheoblast proliferation.This tracheoblast activation relies on the expression of the FGF Iigand bnl in their nearby branches.Finally,we show that,in the absence of the transcription factor Cut (Ct),Bnl/FGF signaling induces endoreplication of tracheoblasts partially by promoting fizzy-reloted expression.Altogether,our results suggest a dual role of Bnl/FGF signaling in tracheoblasts,inducing both proliferation and endoreplication,depending on the presence or absence of the transcription factor Ct,respectively.