Premature ovarian insufficiency,as a complex gynaecological disease,seriously threatens the physical and mental health of women of childbearing age.The main reasons for its pathogenesis are summarized.As a complex gynaecological disease,premature ovarian insufficiency seriously threatens the physical and mental health of women of childbearing age.The causes of the disease mainly include genetic defects,autoimmune disorders,radiotherapy and chemotherapy,infection,surgery,adverse environmental exposures and other factors.In more than half of cases,the cause remains unclear.In the clinic,hormone replacement therapy is used mainly to relieve the symptoms of oestrogen deficiency.This article reviews the research progress on the causes and treatment of premature ovarian insufficiency in recent years.