Molecular mechanism prediction analysis of Xiaozheng decoction in the treatment of bladder cancer based on network pharmacology

• 作者: Guo-Wei Zhang Jia-Yi Shi Miao-Miao Zhang Wan-Ying Zhang Ying Chen
• 来源期刊: 药物联合治疗
• 学科: 医学
• 关键词: Xiaozheng decoction Bladder cancer Network pharmacology TARGETS Signaling pathway
• 年，卷（期）: 2020,（4）
• 页码范围: 185-197
• 页数: 13页
• 分类号: R73

摘要

Background:To investigate the mechanism of Xiaozheng decoction in treatment of bladder cancer based on network pharmacology.Methods:Based on the Tradictional Chinese Medicine Systems Pharmacology Database(TCMSP),the active compositions of Xiaozheng decoction were screened.The targets of active components were obtained from TCMSP,Swiss Target Prediction,and STITCH database.By mapping the disease targets of bladder cancer obtained from the DisGeNET and Genecards databases,the potential targets of Xiaozheng decoction for bladder cancer were obtained.The active components of Xiaozheng decoction-targets network was constructed using the Cytoscape software.The target protein interaction(PPI)network was constructed by using the String online platform,which was visualized by Cytoscape software and analyzed by network topology to obtain the key targets of Xiaozheng decoction.GO bioprocess enrichment analysis and KEGG pathway enrichment analysis were performed on key targets of the Xiaozheng decoction by DAVID database.Results:A total of 68 active components and 255 potential targets of Xiaozheng decoction in the treatment of bladder cancer were retrieved and screened out.The key targets were enriched and analyzed by the GO biological pathway,and 135 pathways were obtained,which involved transcriptional process,platelet activation,cell proliferation,and apoptosis.KEGG pathway enrichment analysis revealed 95 pathways,mainly involving cancer pathway,bladder cancer pathway,MAPK signaling pathway,PI3K-Akt signaling pathway,and VEGF signaling pathway.Conclusion:The result of this study showed that Xiaozheng decoction may play its therapeutic role through multiple components,multiple targets and multiple pathways,and preliminarily explored the mechanism of Xiaozheng decoction in the treatment of bladder cancer,laying a foundation for subsequent experimental studies.