Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

• 作者: Chioma Don-Lawson Daniel Okechukwu Nweneka Kingsley J. Orie Reminus Okah
• 来源期刊: 美国分析化学(英文)
• 学科: 化学
• 关键词: FURFURAL 1 1-bis(2-Carbamoylguanidino)furan-2-ylmethane Bioactivity
• 年，卷（期）: 2020,（6）
• 页码范围: 261-268
• 页数: 8页
• 分类号: O62

摘要

This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, ¹H-NMR, ¹³C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on Escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.