A Simultaneous Multidisciplinary Evaluation of Irritable Bowel Syndrome in Egyptian Patients: Dietary, Psychiatric, Microbiologic and Autonomic Aspects

• 作者: A. Al-Sayyad A. Nawito M. Abdelbary M. Menesy M. Nasreldin R. Marzaban R. Mostafa
• 来源期刊: 肠胃病学期刊(英文)
• 学科: 医学
• 关键词: Irritable Bowel Syndrome (IBS) Eysenck Personality Questionnaire (EPQ) Hopkins Symptom Checklist (HSCL-90) Microbiota Autonomic Activity
• 年，卷（期）: 2020,（8）
• 页码范围: 214-230
• 页数: 17页
• 分类号: R57

摘要

<b><span style="font-family:Verdana;">Background and Aim:</span></b><span style="font-family:Verdana;"> Irritable bowel syndrome (IBS) is a common medical disorder that may be severe enough to impair the quality of life. This study aimed to assess the role of each of dietary, psychiatric, autonomic, and microbiology</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">background and their interactions in Egyptian patients with IBS. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> Forty adult patients diagnosed with IBS, equally divided into 2 groups the diarrhea predominant and the constipation predominant, were recruited from the Endoscopy Unit. Dietary assessment was done by monthly food frequency questionnaire. Psychiatric assessment was done by both the Eysenck Personality Questionnaire (EPQ) and Hopkins Symptom Checklist (HSCL-90). Microbiologic evaluation was done by faecal cultures and neurophysiologic autonomic evaluation was done via the sympathetic skin response and the parasympathetic R-R interval variation. Another 20 healthy subjects were included as control group. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> All IBS patients were young, with significant female predominance (P</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.007), particularly in IBS-C group (20/20;100%, P</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.003). Psychologically, abnormal scores of neuroticism, extraversion and criminality, and depression, obsessive compulsion, somatization, sensitivity and anxiety in both IBS groups with particularly extraversion, criminality and depression were significantly higher in constipation subtype. Microb