The effect of using long-acting octreotide as adjuvant therapy for patients with grade 2 pancreatic neuroendocrine tumors after radical resection

• 作者: Gao Suizhi Shi Xiaohan Ma Hongyun Wang Huan Li Bo Song Bin Guo Shiwei Jin Gang
• 来源期刊: 胰腺病学杂志（英文）
• 关键词: Adjuvant therapy G2 Long-acting octreotide Pancreatic neuroendocrine tumors
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Original Article
• 页码范围: 167-172
• 页数: 6页
• 语种: 中文
• DOI: 10.1097/JP9.0000000000000058

摘要

Objective::To investigate the effect of long-acting octreotide as adjuvant therapy in the prevention of tumor recurrence in patients with grade 2 pancreatic neuroendocrine tumors (pNETs) after radical resection.Methods::The postoperative follow-up data of 130 patients with resectable G2 pNET treated in the Changhai Hospital from 2008 to 2018 were retrospectively analyzed: 59 patients received long-acting octreotide as adjuvant therapy for 6 to 12 months (Oct group) and 71 patients received active follow-up (control group), both of which began after the radical resection, with the primary observation endpoint of disease-free survival (DFS) and the secondary study endpoint of overall survival.Results::The median age of the patients in the Oct group and control group was 52 and 54 years, respectively. There were 28 male cases (47.5%) and 33 male cases (46.5%) in the 2 groups. The median maximum tumor diameter was 3.5 and 3.0 cm, respectively; lymph node metastasis was positive in 13 cases (22.0%) and 9 cases (12.7%); there was peripancreatic nerve invasion in 11 cases (18.6%) and 6 cases (8.5%). Survival analysis revealed that there were significant differences in 2-year DFS% (98.3% vs 88.7%, P=.0371) and 3-year DFS% (96.6% vs 85.9%, P=.0498) between the Oct group and control group. Long-acting octreotide treatment was found to reduce the risk of 3-year recurrence of G2 pNET after radical resection (HR= 0.2, P=.044) with the application of inverse-probability-of-treatment weighted to balance the limited data bias. Conclusion::Using long-acting octreotide as adjuvant therapy for G2 pNET patients after radical surgery may improve the rate of 3y-DFS, but the benefit needs to be confirmed in a well-designed random control clinical trial.