Bloodstream Bacterial Infection in Neutropenic Acute Leukemia Patients

• 作者: Asmaa M. Zahran Hala F. Mohamed Salwa I. Abedelnasser
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: BLOODSTREAM INFECTION (BSI) BLOOD CULTURES Biomarkers MOLECULAR Techniques
• 年，卷（期）: azzlyw_2020,（5）
• 页码范围: 296-305
• 页数: 10页
• 分类号: R73

摘要

Objective: The rapid detection of blood stream infection has the potential to not only improve patient outcomes due to quicker administration of appropriate antibiotics but also improve antibiotic stewardship by reducing patient exposures to ineffective or unnecessary broad-spectrum antibiotics. Methods: In this study blood samples from acute leukemia neutropenic patients (samples under study) and non neutropenic patients (control) were tested using cultural and non-cultural based techniques via blood culture, C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) and Molecular techniques (bacterial 16S rDNA analysis). Results: About 22% & 15% were shown positive in blood culturing;94% & 85% were positive for CRP;86% and 75% were presented by elevation in ESR rate for the first hour;94% and 80% were presented by elevation in ESR rate for second hour. Treatment response of the positive cases by blood culture only was found to be 72.7% and 100% not in remission for samples under study and control respectively. In cases under study there is statistically significant correlation between culture growth sensitivity and PCR technique with P value 0.005.