Role of molecular biomarkers in glioma resection: a systematic review

• 作者: Fang Shengyu Jiang Tao Li Lianwang Li Yiming Wang Yinyan
• 来源期刊: 中华神经外科杂志（英文）
• 关键词: Glioma Molecular biomarkers Guidance Resection
• 年，卷（期）: 2020,（2）
• 所属期刊栏目: Review
• 页码范围: 103-109
• 页数: 7页
• 语种: 中文
• DOI: 10.1186/s41016-020-00198-x

摘要

New discoveries based on genetic and epigenetic evidence have significantly expanded the understanding of diffuse gliomas. Molecular biomarkers detected in diffuse gliomas are not only potential targets for radiotherapy, chemotherapy, and immunotherapy, but are also able to guide surgical treatment. Previous studies have suggested that the optimal extent of resection of diffuse gliomas varies according to the expression of specific molecular biomarkers. However, the specific guiding role of these biomarkers in the resection of diffuse gliomas has not been systemically analyzed. This review summarizes several critical molecular biomarkers of tumorigenesis and progression in diffuse gliomas and discusses different strategies of tumor resection in the context of varying genetic expression. With ongoing study and advances in technology, molecular biomarkers will play a more important role in glioma resection and maximize the survival benefit from surgery for diffuse gliomas.