Conservation Law of Cell Bioelectricity Membrane Area and Ion Inequality Equation Based on Potassium Channel“Origami Windmill”Model

• 作者: Zuodong Sun
• 来源期刊: 美中医学:英文版
• 学科: 数学
• 关键词: K+channel“origami windmill”model ionic theory GHK equation H-H equation conservation law of membrane area ion inequality equation
• 年，卷（期）: 2020,（5）
• 页码范围: 177-192
• 页数: 16页
• 分类号: O17

摘要

At present,there are misunderstandings and even subversive errors in the understanding of cellular bioelectricity phenomena.The theory explaining the mechanism of bioelectricity generation is the ionic theory,and the ionic theory is based on the membrane theory.The membrane theory may be the correct part,and the ionic theory does not give a definite affirmation;the membrane theory may be the wrong part,and ionic theory does not give a clear negative,instead,has been further strengthened in the later period.Whether it is membrane theory or ionic theory,the author has ignored the structure and characteristics of ion channels,and has not found the essence and law of ion exchange inside and outside the cell membrane.Therefore,the GHK equation and the H-H equation based on the ionic theory have congenital deficiencies.Therefore,it is necessary to put forward a new doctrine on this basis and establish a new mathematical model based on the new doctrine to re-explain the mechanism of bioelectricity generation scientifically and rationally.This paper is based on the principle of K+channel“origami windmill”model,the conservation law of membrane area of cell action potential ion exchange was proposed,and establishes a new mathematical model of cell action potential based on the conservation law of membrane area—ion inequality equation.The expression of conservation law of membrane area:SA(t)+SB(t)=S0,the expression of the ion inequality equation:resting potential N=N0+Vt;action potential N=N0+170t-90t2.The conservation law of membrane area holds that bioelectrical activity is a process in which different cations replace each other on the inner surface of the cell membrane.Cl-is already surrounded by the cell membrane at the beginning of cell membrane formation,which determines the“positive”and“negative”of the cell action potential;The cations such as Na+,K+,etc.,the amount of mutual replacement on the inner surface of the cell membrane determines the amplitude of the action potential,and the ratio of mutual re