Molecular modulation of autophagy: New venture to target resistant cancer stem cells

• 作者: Harpreet K Mandhair Miroslav Arambasic Ramin Radpour Urban Novak
• 来源期刊: 世界干细胞杂志:英文版(电子版)
• 学科: 医学
• 关键词: AUTOPHAGY Cancer stem cells Cancer cells Cancer therapy Therapeutic resistance Cancer metastasis
• 年，卷（期）: 2020,（5）
• 页码范围: 303-322
• 页数: 20页
• 分类号: R73-3

摘要

Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis.