A Meta-analysis of Therapeutic Effect of Thalidomide on Ankylosing Spondylitis

• 作者: Xin Liu Yukun Yao
• 来源期刊: 医学科学进展杂志(英文)
• 学科: 医学
• 关键词: META-ANALYSIS Ankylosing spondylitis THALIDOMIDE Clinical efficacy
• 年，卷（期）: yxkxjzzzyw_2020,（3）
• 页码范围: 21-24
• 页数: 4页
• 分类号: R57

摘要

Objective:To study the therapeutic effect of thalidomide on ankylosing spondylitis(AS)by meta-analysis.Methods:Personal digital library,Cochrane library,and China Biology Medicine disc(CMBdisc),as well as relevant pharmaceutical and medical journals,were collected and reviewed.After the analysis of characteristics of the selected document and the evaluation of the risk of bias,the therapeutic effect of thalidomide on ankylosing spondylitis(AS)and its influence on related indexes were analyzed by literature data.Results:The meta-analysis results of 8 pieces of literature showed that the total effective rate of thalidomide in the treatment of ankylosing spondylitis(AS)was significantly improved,compared with conventional treatment or sulfasalazine(SASP)treatment(P<0.05).Furthermore,the time of morning stiffness,BASDAI score,C-reactive protein(CRP)level,and other related symptoms and indexes were significantly optimized(P<0.05).Conclusion:By rational utilization of thalidomide in the treatment of ankylosing spondylitis(AS),related symptoms and indexes of patients can be effectively improved,the total effective rate of the treatment was significantly improved and the safety of the treatment can be guaranteed.