Patient with frontal-variant syndrome in early-onset Alzheimer's disease

• 作者: Han Cai Lin Sun Shifu Xiao Su Ning Wei Li Xia Li
• 来源期刊: 综合精神医学(英文)
• 学科: 医学
• 关键词: ALZHEIMER diagnosis clinical
• 年，卷（期）: zhjsyxyw,（2）
• 页码范围: 114-117
• 页数: 4页
• 分类号: R74

摘要

The clinical manifestation of frontal-variant Alzheimer’s disease(fvAD)is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia(fvFD).We describe a patient with early-onset Alzheimer's disease(AD)who presented with an fvFTD-like syndrome and apolipoprotein E ε3/ε4 genotype.A brain amyloid imaging procedure,11 C-Pittsburgh compound B positron emission tomography(PET),supported the final diagnosis of AD.Our present case highlights the clinical variability that characterises early-onset AD.A multimodal approach is crucial when assessing rare forms of dementia.