An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis

• 作者: Ani Arakelian Moshe Szyf Niaz Mahmood Shafaat A. Rabbani William J. Muller
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（3）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 300-311
• 页数: 12页
• 语种: 英文

摘要

INTRODUCTION Breast cancer is one of the most prevalent malignancies in women worldwide.1 Despite the recent advances in the development of anti-cancer therapeutic agents, the overall survival rate for patients with metastatic breast cancer remains poor, which highlights the need for more innovative and rational therapeutic strategies.2 Among the various nutraceutical agents tested for treatment of breast cancer, Vitamin D (Vit. D) showed significant promise as it decreases cell proliferation, angiogenesis, promotes cellular differentiation and apoptosis, and stimulates immune response.