A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin Ⅱb

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（2）
• 页码范围: 105-118
• 页数: 14页
• 语种: 英文

摘要

Dominance hierarchy is a fundamental phenomenon in grouped animals and human beings,however,the underlying regulatory mechanisms remain elusive.Here,we report that an antisense long non-coding RNA (IncRNA) of synapsin Ⅱ,named as AtLAS,plays a crucial role in the regulation of social hierarchy.AtLAS is decreased in the prefrontal cortical excitatory pyramidal neurons of dominant mice;consistently,silencing or overexpression of AtLAS increases or decreases the social rank,respectively.Mechanistically,we show that AtLAS regulates alternative polyadenylation of synapsin Ⅱ gene and increases synapsin 2b (syn2b)expression.Syn2b reduces AMPA receptor (AMPAR)-mediated excitatory synaptic transmission through a direct binding with AMPAR at the postsynaptic site via its unique C-terminal sequence.Moreover,a peptide disrupting the binding of syn2b with AMPARs enhances the synaptic strength and social ranks.These findings reveal a novel role for IncRNA AtLAS and its target syn2b in the regulation of social behaviors by controlling postsynaptic AMPAR trafficking.