Histological grades and prognostic markers of well-differentiated pancreatic neuroendocrine tumor (WDPNET)

• 作者: Li Yongchao Rowan Daniel Williamson Claire P. Fan Meiyun Saad Ali G. Zhang Lizhi
• 来源期刊: 胰腺病学杂志（英文）
• 关键词: Grading Ki-67 PNETs Prognosis
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Review Article
• 页码范围: 188-194
• 页数: 7页
• 语种: 中文
• DOI: 10.1097/JP9.0000000000000061

摘要

Pancreatic neuroendocrine tumors (PNETs) are the second most common neoplasm of the pancreas after ductal adenocarcinoma. The clinical behavior of PNETs is very difficult to predict, especially for well-differentiated PNETs. Several classification systems have been developed to differentiate benign from malignant PNETs. The current 5th edition WHO (2019) updated the grading system of PNETs which is now entirely based on proliferative rate (either mitotic count or Ki-67 index). In this article, we systemically reviewed the evolution of the histologic classification and grading systems for well-differentiated PNETs. Meanwhile, we also report a comprehensive summary of immunohistochemical and molecular prognostic factors for PNETs patients, including CK19, KIT, PDL1/PD-L1, UCH-L1 and CNPY2. We believe that more reliable grading systems and prognostic markers are emerging and will change the landscape of treatment for well-differentiated PNETs.