Bioactive Constituents of the Seed Kernels from Vernicia fordii

• 作者: Di Zhou Gang Chen Jiayi Li Jing Ding Ning Li Zisong Bai
• 来源期刊: 亚洲传统医药
• 学科: 化学
• 关键词: Vernicia fordii active component CYTOTOXICITY anti-neuroinflammatory activity
• 年，卷（期）: 2020,（5）
• 页码范围: 228-238
• 页数: 11页
• 分类号: O62

摘要

A new compound,(2′R)-(5-oxo-2,5-dihydrofuran-2-yl)methyl octanoate(1),together with 9 known ones(2-10)were isolated from the bioactive extract of the seed kernels from Vernicia fordii.Their structures were determined by spectroscopic analyses,including Nuclear Magnetic Resonance(NMR)and High Resolution Electrospray Ionization Mass Spectroscopy(HRESI-MS).Their cytotoxicities against three human cancer cell lines(A549,HepG2 and Caco2 cells)and anti-neuroinflammatory effects were evaluated.Cytotoxicity assay revealed that compound 9 could inhibit the growth of HepG2 cells,while compound 6 had a moderate inhibitory effect against A549 cells.Further anti-neuroinflammatory activity assay showed that compound 10 exhibited moderate inhibitory effect on the release of NO in LPS-stimulated BV2 microglia cells.