Diagnostic and prognostic role of long noncoding RNA MALAT1 in breast cancer:a meta-analysis

• 作者: Fang-Hua Yang Hui-Jie Fan Qiang Wang Xue-Feng Jiang Ye-Jian Hu Yi-Gui Lai
• 来源期刊: TMR肿瘤
• 学科: 医学
• 关键词: DIAGNOSTIC PROGNOSTIC MALAT1 Breast cancer
• 年，卷（期）: 2020,（6）
• 页码范围: 237-256
• 页数: 20页
• 分类号: R73

摘要

Background:This systematic analysis aspired to investigate the diagnostic and prognostic role of metastasis associated lung adenocarcinoma transcript 1(MALAT1)in breast cancer.Methods:We conducted a search in PubMed,EMBASE,MEDLINE,Web of Science,CNKI,Wanfang and VIP databases to identify eligible articles,and combined the effect sizes using Stata 15.0 and Meta-Disc 1.4.Results:19 articles were identifed in our study,including 9 diagnostic articles and 11 prognostic articles.For the diagnostic meta-analysis,the pooled specificity,sensitivity,diagnostic odds ratio,area under the curve of MALAT1 in confirming breast cancer were 0.77(95%confidence interval(CI):0.68-0.84),0.81(95%CI:0.71-0.88),14.09(95%CI:6.34-31.31)and 0.85(95%CI:0.82-0.88),separately.The subgroup analysis demonstrated that the diagnostic effect of MALAT1 in triple negative breast cancer was higher than in breast cancer.For the survival outcomes meta-analysis,patients with over-expression of MALAT1 had poor overall survival,recurrence free survival,metastasis-free survival,disease specific survival and disease free survival.Conclusion:MALAT1 may serve as a promising biomarker for diagnosis and prognosis for confirming breast cancer.