Effects of Farnesol on Drug-Resistant and Non-Resistant <i>Candida albicans</i>: Implications for Cosmetic and Pharmaceutical Applications

• 作者: Bryan Larsen Dominic Schaut Emma Wittman Francesco De Seta Neela Yar
• 来源期刊: 微生物学(英文)
• 学科: 医学
• 关键词: FARNESOL Candida albicans Antifungal Resistance Persister Phenotype Quorum Sensing
• 年，卷（期）: 2020,（8）
• 页码范围: 383-396
• 页数: 14页
• 分类号: R37

摘要

<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Farnesol is added to numerous consumer products</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">that inten</span><span style="font-family:Verdana;">tionally, or inadvertently come in contact with tissues that may harbor </span><span style="font-family:Verdana;">the opportunistic yeast, </span><i><span style="font-family:Verdana;">Candida albicans</span></i><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> This study explores biological consequences of the exposure of </span><i><span style="font-family:Verdana;">Candida albicans</span></i><span style="font-family:Verdana;"> from community infecti</span><span style="font-family:Verdana;">ons or from a panel of antifungal drug resistant organis</span><span style="font-family:Verdana;">ms on growth and survival of these organisms when exposed to farnesol. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> ATCC supplied </span><i><span style="font-family:Verdana;">Candida albicans</span></i><span style="font-family:Verdana;"> from the MP8 drug resistance panel and an additional 1</span><span><span style="font-family:Verdana;">2 strains of community-acquired </span><i><span style="font-family:Verdana;">Candida albicans</span></i><span style="font-family:Verdana;"> were c</span></span><span style="font-family:Verdana;">ultured in the presence of farnesol. With standard micobiologic techniques and flow cytometry evaluation, a series of experiments considered growth, morphology, viability and entrance into the quiescent persister phenotype of </span><i><span style="font-family:Verdana;">Candida</span></i></span><i><span style="font-family:;" "=""> </span></i><span style="font-family:;" "=""><span style="font-family:Verdana;">with emphasis on differences between drug resistant