A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

• 作者: David Karasik Douglas P. Kiel Evangelia E. Ntzani Evangelos Evangelou Fotis Koskeridis Georgios Markozannes Georgios Ntritsos Maria A. Christou Spyros N. Nikas
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（3）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 356-364
• 页数: 9页
• 语种: 英文

摘要

INTRODUCTION Osteoporosis is the most common metabolic bone disorder globally, causing low trauma fractures that lead to significant morbidity and mortality. Especially in high-income countries, osteoporotic fractures lead to a substantial loss of healthy life-years in older adults.1 Osteoporosis is characterized by impaired bone quality and/or reduced bone mass, resulting from an imbalance between bone formation and resorption. Noninvasive diagnosis of osteoporosis currently relies heavily on measurement of bοne mineral density (BMD) by dual energy X-ray absorptio-metry (DXA), which is the most widely used predictor of osteoporotic fractures.