Cytotoxic immune cell-based immunotherapy for hepatocellular carcinoma

• 作者: Jing Li Longxiang Tao Xuefu Wang
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2020,（4）
• 页码范围: 17-29
• 页数: 13页
• 语种: 英文
• DOI: 10.20517/2394-5079.2019.34

摘要

Hepatocellular carcinoma (HCC) is one of the most common solid tumors with poor clinical prognosis. Novel therapeutic regimens are urgently required for patients with advanced HCC. Both pre-clinical and clinical studies suggest immunotherapy as an attractive alternative for advanced HCC treatment. Natural killer (NK) cells and CD8+ T cells are the most important cytotoxic immune cells involved in cancer treatment and elimination. Reinvigorating the anticancer activity of NK and CD8+ T cells is the fundamental guarantee for the success of immunotherapy in advanced HCC treatment. Therefore, in this review, we aim to summarize the characteristics and roles of NK and CD8+ T cells in HCC development, describe the frontiers of immunotherapy for advanced HCC based on immune checkpoint inhibitors and adoptive cell transfer, and discuss their limitations and scope for future improvement.