BMP-induced Atoh8 attenuates osteoclastogenesis bysuppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

• 作者: Daizo Koinuma Go Jokoji Kohei Miyazono Masato Morikawa Noboru Taniguchi Ryoichiro Kageyama Setsuro Komiya Shingo Maeda Toshiro Ijuin Yuhei Yahiro
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（3）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 365-378
• 页数: 14页
• 语种: 英文

摘要

INTRODUCTION In adult bone, bone remodeling maintains structural integrity via the clearance and repair of damaged bone and regulates mineral homeostasis.1–2 Osteoclastic bone resorption and osteoblastic bone formation occur sequentially in a synchronized manner at adjacent anatomical spots to preserve bone volume (BV).