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摘要:
Acrylamide(AA)is ubiquitous in packaging materials,paints,cosmetics,food and drinking water.However,AA has obvious neurotoxicity,reproductive toxicity and carcinogenicity,which seriously endangers human health.As one of precious traditional Chinese medicines,Gastrodia elata Bl.has been mainly used to lower blood pressure and resist myocardial ischemia.However,the antioxidant activity of Gastrodia elata Bl.on AA-induced DNA damage has not been reported.We found that AA(25,30 and 50 mg/kg)could cause DNA damage and the damage was time/dose dependent.After AA administration,Tail moment,micronuclei formation rate,8-OHdG and MDA level were significantly increased and SOD activity was decreased.Gastrodia elata Bl.decoction,gastrodin and vitamin C could reduce AA-induced DNA damage by decreasing AA-induced increment of tail moment and micronuclei formation rate.What’s more,Gastrodia elata Bl.decoction,gastrodin and vitamin C could lower 8-OHdG and MDA level and improve SOD activity.In conclusion,our research showed that Gastrodia elata Bl.decoction and gastrodin had protective effects on AA-induced DNA damage,and the potential protective mechanism might be related to anti-oxidative stress.
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篇名 The protective effects of Gastrodia elata Bl.decoction and Gastrodin on Acrylamide-induced DNA damage in mice
来源期刊 亚洲传统医药 学科 化学
关键词 DNA damage Gastrodia elata Bl.decoction GASTRODIN acrylamide oxidative stress
年,卷(期) 2020,(6) 所属期刊栏目
研究方向 页码范围 299-308
页数 10页 分类号 O62
字数 语种
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研究主题发展历程
节点文献
DNA
damage
Gastrodia
elata
Bl.decoction
GASTRODIN
acrylamide
oxidative
stress
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
亚洲传统医药
双月刊
1817-4337
沈阳市沈河区文化路103号20信箱
出版文献量(篇)
72
总下载数(次)
1
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