Neurological heterotopic ossification:novel mechanisms, prognostic biomarkers and prophylactic therapies

• 作者: Ker Rui Wong Richelle Mychasiuk Terence J.O'Brien Sandy R.Shultz Stuart J.McDonald Rhys D.Brady
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: REVIEW
• 页码范围: 379-392
• 页数: 14页
• 语种: 英文

摘要

INTRODUCTION Heterotopic ossification (HO) is the pathological formation of bone in muscles and surrounding joints. The ramifications of this ectopic bone formation in soft tissue include swelling, pain, nerve entrapment, contractures, and in some cases, limited range of movement due to bone fusion in the affected area (i.e. ankylosis).