Cardiovascular effects and mechanisms of sodium-glucose cotransporter-2 inhibitors

• 作者: Meng Ran Yang Fan Zhu Da-Long
• 来源期刊: 慢性疾病与转化医学（英文）
• 关键词: Sodium-glucose cotransporter-2 inhibitors Type 2 diabetes Cardiovascular outcomes Mechanisms of cardiovascular benefits
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Review
• 页码范围: 239-245
• 页数: 7页
• 语种: 中文
• DOI: 10.1016/j.cdtm.2020.07.002

摘要

Sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) are a new type of drug for the treatment of diabetes, and they have been proven to have a good hypoglycemic effect. Several lines of clinical evidence have shown that SGLT2 inhibitors can significantly reduce the risks of atherosclerosis, hospitalization for heart failure, cardiovascular death, and all-cause mortality and delay the progression of chronic kidney disease. Because of the protective effects of SGLT2 inhibitors on the heart and kidney, they are being studied for the treatment of heart failure and chronic kidney disease in patients without diabetes. Therefore, it is necessary for cardiologists, patients with diabetes, and nephrologists to fully understand this type of drug. In this review, we summarize the following three aspects of SGLT2 inhibitors: the recent clinical evidence of their cardiovascular benefits, their mechanisms of action, and their safety.