Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas

• 作者: Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 406-415
• 页数: 10页
• 语种: 英文

摘要

INTRODUCTION Osteoarthritis (OA) is one of the most common degenerative joint diseases with increased incidence in the current aging population.1 Knee OA is characterized by pathological changes in most tissues of the joint, including cartilage degradation, synovial inflammation, and subchondral bone structure alteration, which ultimately lead to a narrow joint space and osteophytes, resulting in severe destruction and impaired function.