Endoscopic retrograde cholangiopancreatography guided interventions in the management of pancreatic cancer

• 作者: Ahmad Muneeb Ahsan Wahab Christopher J Haas Fizah S Chaudhary Hamid Ehsan Muhammad Nadeem Yousaf Richard Williams
• 来源期刊: 世界胃肠内镜杂志:英文版(电子版)
• 学科: 医学
• 关键词: Pancreatic cancer Endoscopic retrograde cholangiopancreatography Malignant stricture Biliary drainage Biliary stent Gastric outlet obstruction
• 年，卷（期）: 2020,（10）
• 页码范围: 323-340
• 页数: 18页
• 分类号: R73

摘要

Pancreatic cancer is the leading cause of cancer-related morbidity and mortality with an overall five-year survival of less than 9%in the United States.At presentation,the majority of patients have painless jaundice,pruritis,and malaise,a triad that develops secondary to obstruction,which often occurs late in the course of the disease process.The technical advancements in radiological imaging and endoscopic interventions have played a crucial role in the diagnosis,staging,and management of patients with pancreatic cancer.Endoscopic retrograde cholangiopancreatography(ERCP)-guided diagnosis(with brush cytology,serial pancreatic juice aspiration cytologic examination technique,or biliary biopsy)and therapeutic interventions such as pancreatobiliary decompression,intraductal and relief of gastric outlet obstruction play a pivotal role in the management of advanced pancreatic cancer and are increasingly used due to improved morbidity and complication rates compared to surgical management.In this review,we highlight various ERCP-guided diagnostic and therapeutic interventions for the management of pancreatic cancer.