Teasing apart the multiple roles of Shp2 (Ptpn11) in spermatogenesis

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 122
• 页数: 1页
• 语种: 英文
• DOI: 10.4103/aja.aja_79_19

摘要

Male germ cells are the only adult cells to undergo the intricate process of meiosis,which is preceded by the complex molecular transition from mitotic spermatogonia to spermatocytes.Recent single-cell transcriptomic studies have shown that this transition involves differential expression of thousands of genes.1,2 Pinpointing the specific roles played by key regulators of this process is crucial to further our understanding of male fertility and,in the long-term,to support the development of infertility therapy and in vitro spermatogenesis.