Biointerface engineering nanoplatforms for cancer-targeted drug delivery

• 作者: Catrina Mae STulinao Huaiyu Zhang Jianxun Ding Shujun Dong Weiguo Xu Xiangru Feng Yang Jiang Zhongmin Li
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 医学
• 关键词: Cell membrane-camouflaged nanoplatform BIOFUNCTIONALIZATION Tumor microenvironment Controlled drug delivery Targeted cancer therapy
• 年，卷（期）: 2020,（4）
• 页码范围: 397-415
• 页数: 19页
• 分类号: R73

摘要

Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis.Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery.Keeping in mind the biological framework of the tumormicroenvironment,biomembrane-camouflaged nanoplatforms have been a research focus,reflecting their superiority in cancer targeting.In this review,we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancertargeted drug delivery,which are classified according to the membranes fromdifferent cells.The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed.