A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

• 作者: Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey L.Wrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 429-438
• 页数: 10页
• 语种: 英文

摘要

INTRODUCTION Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism.1–3 Genetic mutations in TGF-βor BMP signaling pathway components cause heritable developmental bone diseases, and dysregulation of TGF-β or BMP signaling is often associated with osteoporosis or osteoarthritis.