Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

• 作者: Li Ke-Yu Liu Xu-Bao Niu Nan Trafton Diego Wang Jian-Xin Yuan Chun-Hui Yuan Jia-Long Zheng Lei
• 来源期刊: 慢性疾病与转化医学（英文）
• 关键词: Pancreatic ductal adenocarcinoma Tumor microenvironment Immunotherapy Cancer vaccine Stimulator of interferon genes
• 年，卷（期）: 2020,（1）
• 所属期刊栏目: Review
• 页码范围: 6-17
• 页数: 12页
• 语种: 中文
• DOI: 10.1016/j.cdtm.2020.01.002

摘要

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma shields PDAC from traditional antitumor therapies like chemotherapy and various strategies that have been proven successful in other types of cancer. Immunotherapy has the potential to treat minimal and residual diseases and prevent recurrence with minimal toxicity, and studies in patients with metastatic and nonresectable disease have shown some efficacy. In this review, we highlighted the main components of the pancreatic tumor microenvironment, and meanwhile, summarized the advances of some promising immunotherapies for PDAC, including checkpoint inhibitors, chimeric antigen receptors T cells, and cancer vaccines. Based on our previous researches, we specifically discussed how granulocyte-macrophage colony stimulating factor based pancreatic cancer vaccine prime the pancreatic tumor microenvironment, and introduced some novel immunoadjuvants, like the stimulator of interferon genes.