Regulation of microtubule array in its self-organized dense active crowds

• 作者: Xiaqing Shi Xin-Chen Jiang Yu-Qiang Ma
• 来源期刊: 中国物理B（英文版）
• 关键词: microtubule array nematic order zippering microtubule growth
• 年，卷（期）: 2020,（7）
• 页码范围: 67-74
• 页数: 8页
• 语种: 英文
• DOI: 10.1088/1674-1056/ab9430

摘要

Microtubule self-organization under mechanical and chemical regulations plays a central role in cytokinesis and cellular transportations.In plant-cells,the pattems or phases of cortical microtubules organizations are the direct indicators of cell-phases.The dense nematic pattem of cortical microtubule array relies on the regulation of single microtubule dynamics with mechanical coupling to steric interaction among the self-organized microtubule crowds.Building upon previous minimal models,we investigate the effective microtubule width,microtubule catastrophe rate,and zippering angle as factors that regulate the self-organization of the dense nematic phase.We find that by incorporating the effective microtubule width,the transition from isotropic to the highly ordered nematic phase (NⅠ phase) with extremely long microtubules will be gapped by another nematic phase which consists of relative short microtubules (NⅡ phase).The NⅡ phase in the gap grows wider with the increase of the microtubule width.We further illustrate that in the dense phase,the collision-induced catastrophe rate and an optimal zippering angle play an important role in controlling the order-disorder transition,as a result of the coupling between the collision events and ordering.Our study shows that the transition to dense microtubule array requires the cross-talk between single microtubule growth and mechanical interactions among microtubules in the active crowds.