Advanced delivery strategies facilitating oral absorption of heparins

• 作者: Bo Tang Guihua Fang
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 文学
• 关键词: HEPARINS Oral delivery Multiple obstacles STABILITY Intestinal epithelia permeability Lymphatic transport
• 年，卷（期）: 2020,（4）
• 页码范围: 449-460
• 页数: 12页
• 分类号: H31

摘要

Heparins show great anticoagulant effect with few side effects,and are administered by subcutaneous or intravenous route in clinics.To improve patient compliance,oral administration is an alternative route.Nonetheless,oral administration of heparins still faces enormous challenges due to the multiple obstacles.This review briefly analyzes a series of barriers ranging from poorly physicochemical properties of heparins,to harsh biological barriers including gastrointestinal degradation and pre-systemic metabolism.Moreover,several approaches have been developed to overcome these obstacles,such as improving stability of heparins in the gastrointestinal tract,enhancing the intestinal epithelia permeability and facilitating lymphatic delivery of heparins.Overall,this review aims to provide insights concerning advanced delivery strategies facilitating oral absorption of heparins.