Forensic interrogation of diabetic endothelitis in cardiovascular diseases and clinical translation in heart failure

• 作者: Merlin C Thomas Pupalan Iyngkaran
• 来源期刊: 世界心脏病学杂志:英文版(电子版)
• 学科: 地球科学
• 关键词: Cardiovascular disease Diabetic heart disease Diabetes mellitus Diastolic heart failure Endothelitis Heart failure with preserved ejection fraction INFLAMMATION
• 年，卷（期）: 2020,（8）
• 页码范围: 409-418
• 页数: 10页
• 分类号: X70

摘要

Diabetic heart disease(DHD)can be classified as a primary consequence from several pathophysiological manifestation of diabetes mellitus(DM)on cardiac tissues or secondarily in extracardiac tissues and is encountered as either primary or secondary complications of DM.Endothelitis is inflammation of the vascular endothelium and is likely to be seen in the majority of patients who start to manifest an end organ complication of DM in this case DHD.Diabetes is a leading cause for many cardiovascular syndromes and diseases including congestive heart failure(CHF)however much remains unknown about the transition from diagnosed DM to clinical state and the contribution of the various mechanical and counterregulatory systems in the manifested complaint.Diastolic heart failure or heart failure with preserved ejection fraction(DHF/HFpEF),accounts for half of all CHF presentations,has DM as a major contributor,however,there remain large gaps in clinical and pathophysiological understanding.This review aims to explore the microscopic aspects in diabetic endothelitis and provide a clinical link to with context to HFpEF.