Angiotensin Converting Enzyme as a Possible Biomarker to Predict Effect of Obstetric Anesthesia on Pregnant Women with COVID-19 Infection

• 作者: JIANG Haixing LIU Yinyin ZHANG Jingjing ZHANG Zongze
• 来源期刊: 武汉大学自然科学学报（英文版）
• 学科: 医学
• 年，卷（期）: 2020,（5）
• 所属期刊栏目: Biomedicine
• 页码范围: 395-403
• 页数: 9页
• 分类号: R44
• 语种: 英文
• DOI: 10.19823/j.cnki.1007-1202.2020.0055

摘要

We retrospectively investigated 68 parturients with or without COVID-19 undergone emergency cesarean section with combined spinal-epidural anesthesia (CSEA) from a single tertiary university hospital in Wuhan,China.The cases were divided into 2 groups: patients with COVID-19 pneumonia (Group 1) and cases without COVID-19 pneumonia (Group 2).The patients in Group 1 were later divided into 2 groups: patients with low-angiotensin converting enzyme (ACE) (Group 3) and patients with normal-ACE (Group 4).The ACE levels,blood pressure and anesthesia management between the patients of Group 1 and Group 2,Group 3 and Group 4 were recorded as the primary outcome.The secondary outcome included perioperative symptoms,laboratory parameters and vital signs.Compared with Group 2,the patients in Group 1 had different ACE level and lower blood pressure after CSEA.Compared with Group 4,the patients in Group 3 showed lower SBP after CSEA (127 vs.130 mmHg,p=0.028),accompanied with more partus matures and younger age (28 vs.32 years,p=0.007).ACE may be a possible biomarker to predict the anesthesia effects on patients with COVID-19 infections undergoing emergency cesarean delivery.