Toward diagnostic relevance of the αVβ5,αVβ3, and αVβ6 integrins in OA:expression within human cartilage and spinal osteophytes

• 作者: Edith Charlier Céline Deroyer Sophie Neuville Zelda Plener Olivier Malaise Federica Ciregia Philippe Gillet Gilles Reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Michel G.Malaise
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 458-472
• 页数: 15页
• 语种: 英文

摘要

INTRODUCTION According to estimates published in 2016, up to 240 million people around the world suffer from osteoarthritis (OA).1 It is the most common chronic joint disease in adults and is characterized by joint pain, short-lived morning stiffness, and functional limitations. OA generally affects one joint, especially the knee or hip but also frequently the hand or spine.