Review: Pathogenesis of cholestatic liver diseases

• 作者: Eduardo A Rodriguez Raquel T Yokoda
• 来源期刊: 世界肝病学杂志:英文版(电子版)
• 学科: 医学
• 关键词: CHOLESTASIS CHOLANGITIS EPIGENOMICS IMMUNOGENETICS PATHOGENESIS Bile acid
• 年，卷（期）: 2020,（8）
• 页码范围: 423-435
• 页数: 13页
• 分类号: R57

摘要

Cholestatic liver diseases(CLD)begin to develop after an impairment of bile flow start to affect the biliary tree.Cholangiocytes actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of CLD.Progressive cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver transplantation.This narrative review will discuss cholangiocyte biology and pathogenesis mechanisms involved in four intrahepatic CLD:Primary biliary cholangitis,primary sclerosing cholangitis,cystic fibrosis involving the liver,and polycystic liver disease.