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摘要:
The lysosome is the most acidic membrane-bound intracellular organelle. Lysosomal acidity is primarily maintained by vacuolar H +-ATPase (V-ATPase) and counter ion channels. There are >60 hydrolytic enzymes in the lysosome for its fundamental digestive role. Lysosomes also play important roles in endocytosis, exocytosis, autophagy, and cell death. Studies that have implicated roles of lysosomes in the female reproductive system are reviewed here. In the ovary, lysosomes are implicated in the preparation of free cholesterol for steroidogenesis and degradation of regulators of steroidogenesis, regulation of follicular atresia, follicle rupture during ovulation, luteal cell survival, and luteal regression. In the oviduct, lysosomes are involved in endocytosis of both serum and oviductal luminal components. In the uterus during the menstrual/estrous cycle, lysosomes are associated with endometrial secretion, apoptosis, and menstruation. In the uterus during early pregnancy, lysosomes are involved in the temporal and directional changes of endocytosis, uterine epithelial acidification upon embryo implantation initiation, and embryo-maternal mutual communications via extracellular vesicles. In the placenta, lysosomes are implicated in nutrient transport and placental separation from the uterus for parturition. In the mammary gland, lysosomes are important for mammary gland development and involution. These findings suggest/demonstrate functions of lysosomes in multiple processes of female reproduction, from ovulation to ovarian steroidogenesis for pregnancy maintenance, and from essential in utero nurturing of developing embryos/fetuses via embryo/fetal-maternal communications, to optional postpartum nurturing of newborns via lactation. Future studies using genetically or modified animal models and pharmacological approaches will provide novel insights into the functions and mechanisms of lysosomes in the mammalian female reproductive system.
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篇名 Functions of Lysosomes in Mammalian Female Reproductive System
来源期刊 生殖与发育医学(英文) 学科
关键词 Autophagy Endocytosis Lysosome Ovary Steroidogenesis Uterus
年,卷(期) 2020,(2) 所属期刊栏目 Review Article
研究方向 页码范围 109-122
页数 14页 分类号
字数 语种 中文
DOI 10.4103/2096-2924.288025
五维指标
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研究主题发展历程
节点文献
Autophagy
Endocytosis
Lysosome
Ovary
Steroidogenesis
Uterus
研究起点
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研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
生殖与发育医学(英文)
季刊
2096-2924
10-1442/R
16开
上海市平凉路1326弄3号楼3楼
2017
eng
出版文献量(篇)
740
总下载数(次)
0
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