Prevalence and Factors Associated with Rotavirus Infection among Vaccinated Children Hospitalized for Acute Diarrhea in Mwanza City, Tanzania: A Cross Sectional Study

• 作者: Adolfine Hokororo Benson R. Kidenya Delfina R. Msanga Dina Mahamba Elice C. Bendera Elizabeth N. Kwiyolecha Florentina Mashuda Mariam M. Mirambo Stephen E. Mshana
• 来源期刊: 儿科学期刊(英文)
• 学科: 文学
• 关键词: ROTAVIRUS VACCINATION DIARRHEA
• 年，卷（期）: 2020,（3）
• 页码范围: 392-403
• 页数: 12页
• 分类号: H31

摘要

<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Rotavirus infection is a leading cause of severe diarrhea culminating to dehydration among children under five years of age. Understanding trends and factors that could assist towards devising effective preventive strategies of Rotavirus infection beyond vaccination is crucial. </span><b><span style="font-family:Verdana;">Objectives: </span></b><span style="font-family:Verdana;">This study was done in an attempt to determine the prevalence and associated factors of Rotavirus infection among vaccinated children aged between 6 weeks and 24 months admitted with acute diarrhea Mwanza, Tanzania. </span><b><span style="font-family:Verdana;">Material and Methods: </span></b><span style="font-family:Verdana;">Across sectional study involving vaccinated children aged 6 weeks to 24 months was conducted in three selected hospitals from July 2017 to January 2018. Socio-demographic and other relevant clinical information were collected using a standardized data collection tool adopted from WHO Rotavirus surveillance tool. Rotavirus infection from the stool was detected using an enzyme immunoassay. Data were analyzed using STATA version 13. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">A total of 301 vaccinated children with acute diarrhea with a median age of 12 [IQR: 8 </span></span><span style="font-family:""><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 17] months were enrolled. Nine (3.0%) and 292 (97.0%) had received one dose and two doses of Rotavirus vaccine, respectively. The prevalence of Rotavirus infection was 74 (24.6%) [95% CI: 20.0 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 29.8]. Independent predictors of Rotavirus infection were: dry season (OR 6.9;95% CI: 2.9 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 16.0;p < 0.001), 3 ≥ children indwelling in