Continuous cultivation without adequate fertilizer application is responsible<span style="font-family:Verdana;"> for plant nutrient depletion and yield decline of major food crops in sub-Saharan Africa. Field experiments were conducted on umbric Cambisol in Babungo and ustic Oxisol in Bansoa in the Western Highlands of Cameroon over two years to evaluate the effects of combined application of leaf biomass of agroforestry species and mineral fertilizers with their economic returns on maize yield performance. Ten treatments encompassing sole mineral fertilizer, sole leaf biomass of <i></i></span><i><i><span style="font-family:Verdana;">Calliandra</span></i><span style="font-family:Verdana;"></span></i>, <i><i><span style="font-family:Verdana;">Leucaena</span></i><span style="font-family:Verdana;"></span></i>, <i><i><span style="font-family:Verdana;">Acacia</span></i><span style="font-family:Verdana;"></span></i> and <i><i><span style="font-family:Verdana;">Cassia</span></i><span style="font-family:Verdana;"></span></i>, leaf biomasses combined with mineral fertilizer and absolute control were laid in a randomized complete block design and replicated three times. Data collected on maize grain yield was subjected to analysis of variance using XLSTAT version 2014 statistical software. In addition, an economic analysis was performed to evaluate the profitability of the different treatment combinations. The results showed significant differences (<i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i> ≤ 0.05) amongst the different treatments on maize yield on both soil types. The highest maize yields which stood at 5.93 t/ha and 6.01 t/ha were recorded in plots treated with <i><span style="font-family:Verdana;">Acacia</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Cassia</span></i><span style="font-family:Verdana;"> plus half recommended mineral fertilizer on umbric Cambisol and ustic Oxisol respectively. Economic analyses show