A practical access to fluoroalkylthio(seleno)-functionalized bicyclo[1.1.1]pentanes

• 作者: Chen Zhu Jige Liu Xinxin Wu Yaohui Xu Zhen Wu
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: COMMUNICATIONS
• 页码范围: 1025-1029
• 页数: 5页
• 语种: 英文

摘要

Rational design of new bioisosteres through introduction of high-value functional groups to bicyclo[1.1.1]pentane (BCP) is of particular use for drug discovery.Disclosed herein is the first access to valuable fluoroalkylthio(seleno)-functionalized BCPs.A range of SCF3,SCF2H,SCFH2,SeCF3,SeC4F9,and SeC8F17 groups are readily incorporated to BCPs under mild conditions.Concomitant installation of a sulfone provides a platform for incorporation of the BCP motif to bioactive molecules.This practical protocol features novel BCP scaffolds,broad substrate scope,excellent atom-economy,simple operation,and gramscale preparation.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Zhen Wu		1	0	0.0	0.0
2	Yaohui Xu		1	0	0.0	0.0
3	Jige Liu		1	0	0.0	0.0
4	Xinxin Wu		1	0	0.0	0.0
5	Chen Zhu		1	0	0.0	0.0