Study on Tongue Coating Microbiota in Patients with Atrophic Gastritis

• 作者: Lingshan Bao Yingcong Yu
• 来源期刊: 微生物学(英文)
• 学科: 医学
• 关键词: Atrophic Gastritis Tongue Coating Microbiota 16S rRNA Sequencing
• 年，卷（期）: 2020,（12）
• 页码范围: 681-690
• 页数: 10页
• 分类号: R57

摘要

<b>Aims:</b> To explore the tongue coating microbiota composition in patients with atrophic gastritis by using the 16S rRNA gene sequencing technology. <b>Methods:</b> The study included 29 atrophic gastritis patients and 29 age and gender-matched non-atrophic gastritis controls. By sequencing the V3-V4 region of the 16S rRNA, we investigated the microbial community structure and diversity on the tongue coating. <b>Results:</b> There was no significant difference in the microbial diversity on the tongue coating between the two groups. However, compared with the control, the atrophic gastritis group had a smaller number of operational taxonomic units (OTUs). At the class level, patients with atrophic gastritis had lower relative abundances of <i>Betaproteobacteria</i> and <i>Spirochaetia</i> than the control group. At the gene level, the abundance of <i>Neisseria</i> and <i>Aggregatibacter</i> in atrophic gastritis group had significantly decreased compared with control ones. Furthermore, functional prediction revealed that 24 metabolic pathways significantly differed between the two groups. <b>Conclusions:</b> Our findings provide novel evidence that tongue coating microbiota may be a biomarker for characterizing patient with atrophic gastritis, but its mechanism needs to be further elaborated.