Anti-inflammatory Effects of Baicalin(In Vitro and In Vivo)

• 作者: Miao Yu-song Ishfaq Muhammad Chen Chun-li Xu Jia Li Ji-chang
• 来源期刊: 东北农业大学学报（英文版）
• 学科: 医学
• 年，卷（期）: 2020,（4）
• 页码范围: 78-87
• 页数: 10页
• 分类号: R285.5
• 语种: 英文

摘要

Baicalin(BA)is commonly used to treat inflammatory diseases and shows anti-inflammatory effects.The present study aimed to evaluate the analgesic and anti-inflammatory activities of BA both in vitro and in vivo.In animal models,acetic acid-induced writhing was used to assess analgesic activity.In addition,a variety of tests including xylene-induced ear edema test,minimum inhibitory concentration(MIC)assays and acetic acid-induced peritoneal capillary hyperpermeability test were used to evaluate anti-inflammatory activity of BA.BA at 0.2 and 0.1 mg ? mL-1 doses expressed analgesic as well as anti-inflammatory activities in mice.In acetic acid induced writhing test,BA applying three times,twice and once a day significantly inhibited the acetic acid-induced writhing response within 15 min by 7.80％(*p＜0.05),7.50％(**p＜0.01)and 6.25％(**p＜0.01).In xylene-induced ear edema test,BA at 0.2,0.1 and 0.05 mg?mL1 decreased ear edema by 45.50％(**p＜0.01),15.20％(*p＜0.05)and 9.10％(*p＜0.05).In acetic acid-induced peritoneal capillary hyperpermeability test,BA exhibited significant inhibition(*p＜0.05 versus control)of inflammation.In MIC assays,the MIC values of baicalin for S.aureus and Escherichia coli were 125 mg ? mL-1,and the MIC values for the control bacteria ATCC25922 and ATCC25923 were 62.5 mg ? mL-1.These findings suggested baicalin might contain analgesic and anti-inflammatory agents which supported its use in traditional medicine.